Imipramine is used to treat depression and night time bed wetting in children.
How it works
Imipramine belongs to a class of medications called tricyclic antidepressants. Imipramine acts by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance. It also decreases one of the stages of sleep where wetting occurs.
Dosage
Always follow the instructions of doctor regarding the dosage and duration.In depression:
Adult: 25 mg three times a day increasing to 150 mg-200 mg a day in divided doses.
Elderly (more than 60 years): Initially 10 mg a day increasing to 30-50 mg a day.
Nightly bed wetting:
Children over 11 years (35-54 kg) - 50-75 mg a day.
Children 8-11 years (25-35 kg) - 25-50 mg a day.
Children 6-7 years (20-25 kg) - 25 mg a day.
Children less than 6 years: not recommended.
Common side effects
Reduction in blood cells (thrombocytopenia), disturbances in sexual function or sex drive (loss of libido), breast swelling in men (gynecomastia), increased production of breast milk (galactorrhea), changes in blood sugar levels (hypoglycemia), weight gain or loss, SIADH (syndrome of inappropriate antidiuretic hormone secretion), disorientation, dizziness, tiredness or sleepiness, weakness, headache, difficulty concentrating, confusion, agitation, mood swings, aggressiveness, difficulty sleeping, delusions, anxiety, restlessness, pins and needles, tremor, muscle spasm or lack of muscle control, speech problems, fits. Anticholinergic effects (dry mouth, constipation, blurred or double vision, sweating, hot flushes, difficulty passing urine, dilation of the pupil of the eye, glaucoma and blockage of the small intestine), feeling of dizziness when getting up (postural hypotension), high or severely low blood pressure, fast/racing heart, palpitations, irregular heart-beats, changes in ECG readings, feeling or being sick, loss of appetite, inflammation of the mucus membranes in the mouth, tongue lesions, impaired liver function, hair loss, ringing in the ears, small purple red spots, bone fractures.
In Children it may cause changes in behavior.
Who should not take
Patients allergic (hypersensitive) to imipramine or any of the excipients or any tricyclic antidepressants.
Patients who had myocardial infarction, any degree of heart block or other cardiac arrhythmias, mania, severe liver disease, narrows angle glaucoma and problem with urine retention.
Patients who are receiving monoamine oxidase inhibitors.
Infants and children under 6 years old.
Imipramine is used to treat depression and night time bed wetting in children.
How it works
Imipramine belongs to a class of medications called tricyclic antidepressants. Imipramine acts by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance. It also decreases one of the stages of sleep where wetting occurs.
Dosage
Always follow the instructions of doctor regarding the dosage and duration.In depression:
Adult: 25 mg three times a day increasing to 150 mg-200 mg a day in divided doses.
Elderly (more than 60 years): Initially 10 mg a day increasing to 30-50 mg a day.
Nightly bed wetting:
Children over 11 years (35-54 kg) - 50-75 mg a day.
Children 8-11 years (25-35 kg) - 25-50 mg a day.
Children 6-7 years (20-25 kg) - 25 mg a day.
Children less than 6 years: not recommended.
Common side effects
Reduction in blood cells (thrombocytopenia), disturbances in sexual function or sex drive (loss of libido), breast swelling in men (gynecomastia), increased production of breast milk (galactorrhea), changes in blood sugar levels (hypoglycemia), weight gain or loss, SIADH (syndrome of inappropriate antidiuretic hormone secretion), disorientation, dizziness, tiredness or sleepiness, weakness, headache, difficulty concentrating, confusion, agitation, mood swings, aggressiveness, difficulty sleeping, delusions, anxiety, restlessness, pins and needles, tremor, muscle spasm or lack of muscle control, speech problems, fits. Anticholinergic effects (dry mouth, constipation, blurred or double vision, sweating, hot flushes, difficulty passing urine, dilation of the pupil of the eye, glaucoma and blockage of the small intestine), feeling of dizziness when getting up (postural hypotension), high or severely low blood pressure, fast/racing heart, palpitations, irregular heart-beats, changes in ECG readings, feeling or being sick, loss of appetite, inflammation of the mucus membranes in the mouth, tongue lesions, impaired liver function, hair loss, ringing in the ears, small purple red spots, bone fractures.
In Children it may cause changes in behavior.
Who should not take
Patients allergic (hypersensitive) to imipramine or any of the excipients or any tricyclic antidepressants.
Patients who had myocardial infarction, any degree of heart block or other cardiac arrhythmias, mania, severe liver disease, narrows angle glaucoma and problem with urine retention.
Patients who are receiving monoamine oxidase inhibitors.
Infants and children under 6 years old.