Trimetazidine is used for symptomatic treatment of stable angina (chest pain) as an additional therapy to other frontline medicines.
How it works
Trimetazidine belongs to metabolic modulators class of medicines also known as pFOX inhibitors (partial fatty-acid-oxidation inhibitor). In myocardium (muscles of the heart), trimetazidine partially inhibit the metabolic process (?-oxidation) of fatty acid that requires more oxygen consumption) by blocking a specific enzyme (long-chain 3-ketoacyl-CoA thiolase) and thereby triggering glucose oxidation that requires less oxygen consumption. Angina is caused due to decreased oxygen supply to the cells of the heart as a result of reduced blood flow. Trimetazidine, thus triggers processes that increase cellular energy (potentiation of glucose oxidation), thereby acts by preserving the myocardial high-energy and makes oxygen available for the cells of the heart.
Dosage
Always follow the instructions of doctor regarding the dosage and duration.
Adult: 20-35 mg twice daily with meals.
Common side effects
Dizziness, headache, abdominal pain, diarrhea, dyspepsia, nausea and vomiting, rash, itching of skin, pale red, raised, itchy skin rash (urticaria), weakness, palpitations, low blood pressure with change of position, that may be associated with a feeling of discomfort, dizziness or fall, in particular in patients taking antihypertensive treatment (blood pressure medicine), flushings, sleep disorders, constipation, severe allergic skin reactions, swelling of lips and eyes (angioedema), abnormal blood counts, inflammation of liver (hepatitis).
Who should not take
Patients with known hypersensitivity to trimetazidine or to any of the ingredients of the medicine.
Patients with Parkinson disease, parkinsonian symptoms, tremors, restless leg syndrome, and other related movement disorders.
Patients with severe kidney problems.
Pregnant and breastfeeding women.
Children below 18 years of age.
Trimetazidine is used for symptomatic treatment of stable angina (chest pain) as an additional therapy to other frontline medicines.
How it works
Trimetazidine belongs to metabolic modulators class of medicines also known as pFOX inhibitors (partial fatty-acid-oxidation inhibitor). In myocardium (muscles of the heart), trimetazidine partially inhibit the metabolic process (?-oxidation) of fatty acid that requires more oxygen consumption) by blocking a specific enzyme (long-chain 3-ketoacyl-CoA thiolase) and thereby triggering glucose oxidation that requires less oxygen consumption. Angina is caused due to decreased oxygen supply to the cells of the heart as a result of reduced blood flow. Trimetazidine, thus triggers processes that increase cellular energy (potentiation of glucose oxidation), thereby acts by preserving the myocardial high-energy and makes oxygen available for the cells of the heart.
Dosage
Always follow the instructions of doctor regarding the dosage and duration.
Adult: 20-35 mg twice daily with meals.
Common side effects
Dizziness, headache, abdominal pain, diarrhea, dyspepsia, nausea and vomiting, rash, itching of skin, pale red, raised, itchy skin rash (urticaria), weakness, palpitations, low blood pressure with change of position, that may be associated with a feeling of discomfort, dizziness or fall, in particular in patients taking antihypertensive treatment (blood pressure medicine), flushings, sleep disorders, constipation, severe allergic skin reactions, swelling of lips and eyes (angioedema), abnormal blood counts, inflammation of liver (hepatitis).
Who should not take
Patients with known hypersensitivity to trimetazidine or to any of the ingredients of the medicine.
Patients with Parkinson disease, parkinsonian symptoms, tremors, restless leg syndrome, and other related movement disorders.
Patients with severe kidney problems.
Pregnant and breastfeeding women.
Children below 18 years of age.