Itraconazole()
Uses
Itraconazole is an antifungal agent used to treat infections caused by fungus, which can invade any part of the body including the lungs, mouth or throat, toenails, or fingernails.
How it works
Itraconazole acts mainly by preventing the growth of fungi. It prevents the synthesis of an essential component of fungal cell membrane (ergosterol); this results in increased cellular permeability causing leakage of cellular contents from fungal cell, ultimately preventing fungal growth.
Dosage
Always follow the instructions of doctor regarding the dosage and duration.
For superficial fungal infections:
Adults: 100-200 mg per day in divided doses for 14-28 days.
For deep fungal infections:
Adults: 100-200 mg per day. Treatment can go upto 8 months depending on the severity of infection.
Children: Not recommended.
Common side effects
Headache, pain in the abdomen, urge to vomit (nausea), diarrhea, change in taste, shortness of breath, increase in blood levels of liver enzymes, yellowing of the skin and eyes (jaundice), fever and rash, inflammation of sinuses, upper respiratory tract infection, running nose (rhinitis), severe allergic reaction (hypersensitivity), vomiting, constipation, indigestion (dyspepsia), flatulence, pale red, raised, itchy skin rash.
Who should not take
Patients with history or evidence of ventricular dysfunction such as congestive heart failure (failure of the heart resulting in fluid build-up in the lungs, other body tissues, or both) should not take itraconazole for the treatment of fungal infections of the nails (onychomycosis). Coadministration of itraconazole with drugs such as methadone, disopyramide, dofetilide, dronedarone, quinidine, ergot alkaloids (such as dihydroergotamine, ergometrine (ergonovine), ergotamine, methylergometrine (methylergonovine), irinotecan, lurasidone, oral midazolam, pimozide, triazolam, felodipine, nisoldipine, ranolazine, eplerenone, cisapride, lovastatin, simvastatin is contraindicated as itraconazole can cause elevated increase the concentrations of these drugs and may increase or prolong both the effects and/or adverse reactions to these drugs.
Itraconazole is contraindicated in patients with kidney or liver problems.
Patients who have known allergy to itraconazole or any other antifungal medicines.
Children, unless the benefits out weigh the potential risks.
Itraconazole()
Uses
Itraconazole is an antifungal agent used to treat infections caused by fungus, which can invade any part of the body including the lungs, mouth or throat, toenails, or fingernails.
How it works
Itraconazole acts mainly by preventing the growth of fungi. It prevents the synthesis of an essential component of fungal cell membrane (ergosterol); this results in increased cellular permeability causing leakage of cellular contents from fungal cell, ultimately preventing fungal growth.
Dosage
Always follow the instructions of doctor regarding the dosage and duration.
For superficial fungal infections:
Adults: 100-200 mg per day in divided doses for 14-28 days.
For deep fungal infections:
Adults: 100-200 mg per day. Treatment can go upto 8 months depending on the severity of infection.
Children: Not recommended.
Common side effects
Headache, pain in the abdomen, urge to vomit (nausea), diarrhea, change in taste, shortness of breath, increase in blood levels of liver enzymes, yellowing of the skin and eyes (jaundice), fever and rash, inflammation of sinuses, upper respiratory tract infection, running nose (rhinitis), severe allergic reaction (hypersensitivity), vomiting, constipation, indigestion (dyspepsia), flatulence, pale red, raised, itchy skin rash.
Who should not take
Patients with history or evidence of ventricular dysfunction such as congestive heart failure (failure of the heart resulting in fluid build-up in the lungs, other body tissues, or both) should not take itraconazole for the treatment of fungal infections of the nails (onychomycosis). Coadministration of itraconazole with drugs such as methadone, disopyramide, dofetilide, dronedarone, quinidine, ergot alkaloids (such as dihydroergotamine, ergometrine (ergonovine), ergotamine, methylergometrine (methylergonovine), irinotecan, lurasidone, oral midazolam, pimozide, triazolam, felodipine, nisoldipine, ranolazine, eplerenone, cisapride, lovastatin, simvastatin is contraindicated as itraconazole can cause elevated increase the concentrations of these drugs and may increase or prolong both the effects and/or adverse reactions to these drugs.
Itraconazole is contraindicated in patients with kidney or liver problems.
Patients who have known allergy to itraconazole or any other antifungal medicines.
Children, unless the benefits out weigh the potential risks.