Plaque, tuberculosis, tularaemia, sub acute bacterial endocarditis, meningitis, brucellosis.Mycobacterium avium complex infections.
How it works
Streptomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Streptomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Common side effects
Vertigo, Ataxia, Tinnitus, Urinary retensionX, Pain, Giddiness, Nystagmus, Pleocytosis, Neck pain.
Who should not take
Hypersensitivity
Plaque, tuberculosis, tularaemia, sub acute bacterial endocarditis, meningitis, brucellosis.Mycobacterium avium complex infections.
How it works
Streptomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Streptomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Common side effects
Vertigo, Ataxia, Tinnitus, Urinary retensionX, Pain, Giddiness, Nystagmus, Pleocytosis, Neck pain.
Who should not take
Hypersensitivity