Metronidazole + Furazolidone(30 Mg, 100 Mg)
Uses
Amoebiasis, giardiasis, trichomonas vaginitis, anaerobic infections, ulcerative gingivitis.Eradication of H.pylori associated with peptic ulcer disease.Antibiotic-associated coulitis. Trichomoniasis, Balantidiasis, Blastocyatis hominis infection. Adjunct to treatment of chronic periodontal infections. Rosacea.
How it works
Metronidazole enters the cells of microorganisms that contain nitroreductase, where its nitro group is reduced. Unstable intermediate compounds are formed which bind to DNA and inhibit synthesis, causing cell death. Furazolidone and its related free radical products are believed to bind DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug leading to high levels of mutations (transitions and transversions) in the bacterial chromosome.
Common side effects
GI disturbances e.g. nausea, unpleasant metallic taste, vomiting, diarrhoea or constipation. Furred tongue, glossitis, and stomatitis due to overgrowth of Candida. Rarely, antibiotic-associated colitis. Weakness, dizziness, ataxia, headache, drowsiness, insomnia, changes in mood or mental state. Numbness or tingling in the extremities, epileptiform seizures (high doses or prolonged treatment). Transient leucopenia and thrombocytopenia. Hypersensitivity reactions. Anaphylaxis.
Who should not take
History of hypersensitivity to metronidazole or other nitro-imidazole derivatives. Preganancy (1st trimester) & lactation
Metronidazole + Furazolidone(30 Mg, 100 Mg)
Uses
Amoebiasis, giardiasis, trichomonas vaginitis, anaerobic infections, ulcerative gingivitis.Eradication of H.pylori associated with peptic ulcer disease.Antibiotic-associated coulitis. Trichomoniasis, Balantidiasis, Blastocyatis hominis infection. Adjunct to treatment of chronic periodontal infections. Rosacea.
How it works
Metronidazole enters the cells of microorganisms that contain nitroreductase, where its nitro group is reduced. Unstable intermediate compounds are formed which bind to DNA and inhibit synthesis, causing cell death. Furazolidone and its related free radical products are believed to bind DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug leading to high levels of mutations (transitions and transversions) in the bacterial chromosome.
Common side effects
GI disturbances e.g. nausea, unpleasant metallic taste, vomiting, diarrhoea or constipation. Furred tongue, glossitis, and stomatitis due to overgrowth of Candida. Rarely, antibiotic-associated colitis. Weakness, dizziness, ataxia, headache, drowsiness, insomnia, changes in mood or mental state. Numbness or tingling in the extremities, epileptiform seizures (high doses or prolonged treatment). Transient leucopenia and thrombocytopenia. Hypersensitivity reactions. Anaphylaxis.
Who should not take
History of hypersensitivity to metronidazole or other nitro-imidazole derivatives. Preganancy (1st trimester) & lactation